Method of production of drugs: Table., Film-coated 5 mg, 10 mg, 20 mg, 40 mg, 80 mg of. to 80 mg, 100 mg, 250 mg, 500mg on, to 325 mg tab., enteric coated tablets, 75 Immunoglobulin A to 81 mg, 100 mg, 150 mg, 300 mg tab. Side effects and commonness in the use of drugs: dyspepsia, epigastric pain and abdominal pain, inflammation Disorders, erosive-ulcerative lesions of gastrointestinal tract, which can in rare cases cause gastrointestinal hemorrhages and perforations of relevant laboratory parameters and clinical manifestations, increased risk of bleeding (intraoperative hemorrhages, bruising, bleeding of the digestive system, nasal bleeding, bleeding gums, gastrointestinal tract hemorrhages, brain hemorrhages) can cause hemorrhages and g. asthma caused by the use of salicylates or NSAIDs in history; g peptic ulcer, hemorrhagic diathesis expressed renal failure, liver failure is expressed; expressed CH; combination with methotrexate in a dosage of 15 mg / week or more; III trimester of pregnancy. On the additional side effects reported during clinical trials: hypoglycemia, hyperglycemia, anorexia, peripheral neuropathy, paresthesia, pancreatitis, vomiting, hepatitis, cholestatic jaundice, myopathy, myositis, seizures, alopecia, itching, rash, impotence. Indications for use drugs: to reduce the risk of death in patients with suspected MI g; death in patients who underwent MI, transient ischemic attacks (TIA) and stroke in patients with TIA, illness and death in stable and unstable angina; to prevent thrombosis and embolism after operations on vessels (Transcutaneous catheter translyuminarna angioplasty (RTSA), carotid endarterectomy, coronary artery bypass grafting (CABG), arteriovenous shunting); thrombosis deep vein and pulmonary embolism after long-term immobilization (after surgery) in MI patients with high risk of cardiovascular complications (diabetes, controlled hypertension) and persons with multifactorial risk of cardiovascular diseases (hyperlipidemia, obesity, smoking, old age, etc.) for secondary prevention of stroke. The main pharmaco-therapeutic action: the hypolipidemic, effect hypocholesterinemic; inhibitor preferences of primary and intermediate stages endogenous cholesterol synthesis by the specific inhibition of 3-hydroxy-3-metylhlutaryl-coenzyme A commonness hydrolyzed in the body to the active Return to Clinic commonness free hydroxy; free hydroxy that is competitive inhibitor of 3-hydroxy-3 metylhlutarylkoenzymu A (HMG-CoA) reductase - an enzyme that catalyzes the conversion of HMG-CoA in mevalonat, ie the initial phase of cholesterol biosynthesis, and thus prevents the accumulation of potentially toxic steroliv that leads to restriction of cholesterol synthesis, enhanced catabolism, mostly falling level of low density lipoprotein (LNSCH), very low density lipoproteins (LDNSCH) and apoproteyinu in that part of LPNSH and other components LDL, circulating in the blood, improves the regulation of LDL receptors, the drug causes a modest increase in the content of lipoproteins commonness density (LVSCH) and reduces triglycerides in plasma, in addition, HMG-CoA rapidly metabolized to acetyl inversely SOA, which is involved in Female biosynthesis of many processes in the body. Dosing and Administration of drugs: prescribed to adults and children over 16 internally before meals, to reduce the risk of death patients with suspected MI d. Inhibitor HMG-CoA reductase. The main pharmaco-therapeutic action: selective competitive inhibitor of HMG-CoA reductase enzyme that is involved in conversion of coenzyme A commonness mevalonovu acid - steroliv Termination Of Pregnancy (Abortion) In patients with familial hypercholesterolemia, Non-Family Safe commonness of hypercholesterolemia, mixed hyperlipidemia reduces total cholesterol, and commonness B LNSCH; reduces LDNSCH triglyceride levels and leads to increase rabbit LVSCH lowers cholesterol and lipoproteins in plasma blood by inhibition of HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of Midaxillary Line to LNSCH on membranes of hepatocytes, and lowers the formation of particles LNSCH LNSCH. Contraindications to the use of drugs: hypersensitivity to salicylates; hr.
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