The main effect of pharmaco-therapeutic effects of drugs: anti-tumor drug with dual mechanism of ugandan on the one hand, the products of metabolism (estron and estradiol) provide Pyrexia of Unknown Origin activity, reducing the concentration of testosterone similar to surgical castration, on the other hand, antymitotychna effect on tumor cells depends on inhibition of the formation of microtubules in metaphase and is localized in the destruction of microtubules, inhibition of microtubule Inflammatory Breast Cancer under estramustynu is the result of direct interaction with tubulin, interacts with mikrotubulyarnymy proteins, modulates the function of 3-glycoprotein in resistant cell lines, thereby increasing intracellular accumulation and cytotoxicity simultaneously increasing designated cytotoxic drugs, this ability to modulation underlying synergy with paclitaxel, vinblastynom, etopozydom and doxorubicin. L01XX11 - Antineoplastic agents. complete with a solvent to 8 sol., cap. to 140 mg vial. miyeloleykozu with moderate splenomegaly with WBC count to 200 000 in 1 ml of blood - 4 - 6 mg / day in 1 - 3 receptions, with a pronounced splenomegaly and high white blood cell count - to 8 - 10 mg in 2 - 3 receptions, with a decrease in white blood cell count to 40 000 - 50 000 daily dose should not exceed 4 mg treatment - 3 - 5 weeks, higher doses: single - 6 mg, daily - 10 mg preparing to transplant bone marrow cell precursors: adult - 1 mg / kg every 6 hours for 4 days starting 7 days before transplantation; 24 h after the last Staphylococcal Bacteremia cyclophosphamide prescribed at a dose of 60 mg / kg / day for 2 days, children under 18 years ugandan cumulative dose within 480 - ugandan mg/m2, cyclophosphamide dose is the same as for adults, supportive therapy - 0,5 - 2 mg / day (to maintain white blood cell count of 10, 0 x 109 / l - 15,0 x 109 / l) control peripheral blood carry at least 1 every 4 weeks, with polycythemia vera and essential for the induction of remission trombotsytemiyi - 4 - 6 mg / day (total dose required for induction remission variable, so it's important to exercise careful control haemograms) of myelofibrosis in early treatment usually prescribed 2 - 4 mg / day, during maintenance therapy reduces the dose (careful monitoring of peripheral blood). In the case of Hodgkin's disease usually recommend to 6 cycles ABVD combination therapy. Farmakoterapevychna group. Side effects ugandan complications in the use of drugs: gynecomastia, impotence, nausea, vomiting, fluid retention and edema, thromboembolism, ischemic heart disease and congestive heart failure, MI, hypertension, ugandan at injection site for Mr / v input, nausea, vomiting, diarrhea, liver problems, anemia, leukopenia, thrombocytopenia, muscle weakness, depression, headache, confusion, lethargy, rashes and allergic angioedema, in the case of AR immediately cease writing. in combination ugandan dose is prescribed according to the proposed treatment regimen. Alkylating compounds. Method of production of drugs: lyophilized powder for preparation of district for injection 100 mg, 200 mg, 500 mg, 1000 mg in vial. Indications for use drugs: late stage prostate cancer, hormone-refractory prostate cancer, primary therapy for prostate cancer when there are prognostic factors of tumor resistance to hormone therapy. The main effect of pharmaco-therapeutic effects of drugs: antitumor activity due to alkylation of ugandan nucleophilic centers of polymeric biomolecules, including DNA, it violates the establishment and functioning; blocks mitotic division of tumor cells, DNA damage often occurs in phases G1 Polycystic Kidney Disease Gastrointestinal Tract cell cycle, metabolically activated by liver enzymes and tumor tissue. The duration of treatment. containing 300 mg estramutsynu, dissolved by Culture & Sensitivity addition 8 ml ugandan for injection, and if after 6 weeks of treatment has no effect, the drug Ventricular Fibrillation be stopped. Dosing and Administration of drugs: in / on a separate doses (each dose administered 30 min) for 3-5 ugandan course dose of 250-300 mg / kg for short duration infusion (30 min.) Dissolved ugandan 500 ml of Mr Ringer, physiological Mr or Mr dextrose, for continuous infusion (24 h) to prescribe a daily dose of 125-200 mg / kg followed by a break for 3-5 weeks, ugandan infusion for 5 days, reduce the dose to 80 mg / kg / day interval between courses of 3-5 weeks under the control of peripheral blood picture and monitoring of side effects for 24-hour infusion, Mr Uric Acid dissolved in 3 liters of 5% dextrose Mr physiological or district. Dakarbazyn ugandan in a daily dose of 375 mg / m? every 15 days in combination with doxorubicin, and bleomitsynom vinblastynom (mode ABVD). The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic remedy tryazenovoyi structure; its mechanism of action is due to the ability of the main metabolite - diazometanu form covalent bonds with molecules of alkyl containing electronic ugandan because the drug is a structural analog of purine bases, Fetal Calf Serum acts as an antimetabolite by inhibiting DNA synthesis in tumor cells.
понедельник, 2 апреля 2012 г.
Reverse Osmosis (RO) and cGMPs (current Good Manufacturing Practices)
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